The list of upregulated genes upon MDMX knockdown contains 66 genes potentially regulated directly by p53 of which multiple genes are among the most commonly found p53-activated genes, namely, CDKN1A, TP53INP1, TSPAN11, EDA2R and CYFIP2 [61], indicating that p53 transactivation is repressed by MDMX in our uveal melanoma cells as expected. The gene discussed is MDM4; the disease is uveal melanoma.