TFF1 and colorectal carcinoma: Together, these results show that the NF-κB pathway and TFF1 expression are inversely related: an increase in TFF1 levels suppresses the expression of NF-κB pathway components and, conversely, suppression of NF-κB signaling restores/elevates the expression of TFF1 RNA (Figure 4B, Supplementary Table S2) and protein levels (Figure 4C,D) in L1-expressing CRC cells.