They reported that in uterine carcinosarcomas with an endometrioid epithelial part, mutations in PTEN, KRAS, ARID1A, and PIK3CA were prevalent, whereas in uterine carcinosarcomas with a serous epithelial component, mutations in TP53, PIK3CA, FBXW7, CHD4, and PPP2R1A predominated [21]. The gene discussed is PTEN; the disease is uterine carcinosarcoma.