CD8A and cancer: Moreover, IL-10 can regress cancer growth by inhibiting IL-6 release while activating STAT3 signaling in cervical carcinoma [37].MDSCs are responsible for the insufficient stimulation of APCs and immune reactions to tumor antigens, the impaired activation of CD8+T cells, and, ultimately, for hampering the therapeutic efficacy of immunotherapy in HPV-mediated cervical cancer [38].