Nevertheless, in a previous study targeting diffuse large B-cell lymphoma (DLBCL), patients who received modulated chemotherapy with low a dose of cyclophosphamide (500 mg/m2) and fludarabine (30 mg/m2) had a higher level of cytokines, particularly IL-5 and IL-15, which are critical for T cell proliferative cytokines [34,44]. This evidence concerns the gene IL15 and diffuse large B-cell lymphoma.