Consistent with the GSEA analysis of pan-cancers, Supplementary Figure S5 shows that PTX3 is correlated with diverse tumor signaling pathways such as “inflammatory response”, “IL-10 anti-inflammatory signaling”, “TGF-β”, “ferroptosis”, and “apoptosis”, whereas, a more real mechanism of PTX3 in KIRC remains to be explored in the future. This evidence concerns the gene IL10 and cancer.