In this study, we found that PTX3 and its interacting genes primarily focused on tumor progression and the immune response, including “complement activation”, “humoral immune response”, “acute inflammatory response”, the “PI3K-AKT signaling pathway”, the “MAPK signaling pathway”, etc. Consistent with our results, PTX3 was identified as a possible common mediator between systemic inflammation and cancer [27]. Here, AKT1 is linked to neoplasm.