Supplementary Figure S2C depicted the genomic alterations in PTX3, including their locations, types, and numbers. We detected, altogether, 47 mutation sites including 44 missenses, one truncating, one inframe, and one splice mutation between amino acids 0 and 381. The main genetic changes identified in the PTX3 gene were missense mutations. The R188C/H alteration in the pentaxin domain was detected, which was detected in one case of UCEC and one case of CESC. Importantly, PTX3 CNV was associated with poor prognosis in LGG, KIRP, PAAD, SARC, THYM, UCEC, and UVM (Supplementary Figure S3). Here, PTX3 is linked to pancreatic adenocarcinoma.