In colorectal cancer patients, the level of IL-6 is significantly and positively correlated (p = 0.004, Spearman r = 0.479) with IL-8, and similarly the IL-8 with the intake of betaine and B9 (folate) (p = 0.028, Spearman r = 0.369 and p = 0.032, Spearman r = 0.378, respectively). This evidence concerns the gene CXCL8 and colorectal cancer.