Particularly for the homozygous mutant genotype for TLR4—D299G, TLR4—T399I, TLR9—T1237C, TLR9—T1486C, and TLR2-196 to-174 bp the detection was up to 56.8% in CRC patients, while none of healthy donors were detected with any of the variations. This evidence concerns the gene TLR9 and colorectal carcinoma.