U2AF1 and cancer: Based on the somatic mutation data at the DNA level of 12 cancer types in the Cancer Genome Atlas database (TCGA), U2AF1 mutations are found in 7 cancer types, including AML, lung adenocarcinoma, endometrial carcinoma, bladder urothelial carcinoma, head and neck squamous cell carcinoma, colon cancer, and invasive breast carcinoma [11].