Ketogenic diet could be an effective adjuvant anticancer therapy, reducing glucose uptake (Warburg effect) and production of pro-inflammatory cytokines (TNFα, IL-1β, IFN-γ, COX-2) and regulating the expression of many factors and proteins, including matrix metalloproteinases, histone deacetylases, pyruvate kinase, p53, and AMP-activated protein kinase, involved in tumor growth and progression. The gene discussed is IFNG; the disease is neoplasm.