The inhibitory effect of the AEDs on PSA serum levels in individuals receiving long-term treatment with anticonvulsant drugs, as well as their antiproliferative activity on PCa cells in vitro and in vivo, also accompanied by a significant reduction in mRNA and protein synthesis of PSA, has been related to AEDs potential to reduce PCa risk [180]. The gene discussed is KLK3; the disease is posterior cortical atrophy.