For miR-17/miR-21, the common nodal target is Pten, which is an established potent tumor suppressor, mostly known as a regulator of the PI3K/Akt pathway and as possessing multiple interconnections with miR-17- and miR-21-regulated targets, accounted for 16 interconnections in total (Figure 8b,c). The gene discussed is PTEN; the disease is neoplasm.