ALPK1 and chronic kidney disease: However, the ALPK1 missense variants rs2074379 (M732I) and rs2074388 (G565D) have been reported to be significantly associated with gout [31], chronic kidney disease [32], and diabetes [33], while the rs2074388 (G565D) variant has also been associated with colon cancer [23], suggesting that ALPK1 is closely related to chronic kidney disease and diabetes.