By assessing the effect of knockdown of 420 kinases in bilineage triple-negative breast cancer cells expressing myoepithelial and luminal cell characteristics, Strietz et al. [24] revealed that restricting the expression of ERN1 and ALPK1 independently resulted in anchorage-independent loss of growth and reduced tumorigenicity. The gene discussed is ALPK1; the disease is triple-negative breast carcinoma.