The same research group [33] found that the rs2074379 (M732I) and rs2074388 (G565D) ALPK1 variants were significantly associated with the prevalence of type 2 diabetes by conducting a longitudinal analysis using generalized estimating equations and adjusting for age, gender, and body mass index in 797 subjects with type 2 diabetes and 5230 controls. Here, ALPK1 is linked to type 2 diabetes mellitus.