By assessing the effect of knockdown of 420 kinases in bilineage triple-negative breast cancer cells expressing myoepithelial and luminal cell characteristics, Strietz et al. [24] revealed that restricting the expression of ERN1 and ALPK1 independently resulted in anchorage-independent loss of growth and reduced tumorigenicity. This evidence concerns the gene ERN1 and triple-negative breast carcinoma.