FGF1 and colorectal carcinoma: Further indications of the promoting proliferation functions of CAFs on CRC acting as mediators include the microRNA-31, ncRNA UCA1 and a few signaling pathways, such as PI3K-Akt, FGF-1/-3/FGFR4 and ERK5/PD-L1 [139,140,141,142,143].