The application in CRC cells of the previously mentioned stimulation of cancer stemness through the paracrine interplay among CAFs and cells of numerous cancers revealed that CAFs can increase their stemness both in vitro and in vivo, according to mouse models, through the upregulation of netrin-1 as well as by transferring exosomal IncRNA H19 (acting as an inhibitor on stemness) [174]. Here, NTN1 is linked to cancer.