AFP and hepatocellular carcinoma: Finally, a machine-learning analysis showed that factors such as comorbidities and high pre-resection AFP, as well as post-resection factors such as TBS and lymphovascular invasion, could be the best predictors of OS in patients with BCLC-A, and TBS was the single best predictor of outcomes in patients with BCLC-B undergoing resection for HCC [58].