IFNG and hepatocellular carcinoma: Another study performed by Xu et al. evaluated the efficacy of IFN-producing killer DCs (IKDCs, a subset of immune cells with certain phenotypes and functions of both DCs and NKs), which were transfected with lentiviral vector DNA containing a gene encoding the T-box family transcription factor T-bet for IFN-γ induction, in treating HCC [57].