Another two studies performed by Teng et al. evaluated the efficacy of a mature-DC vaccine, which was pulsed with total cell lysate prepared from mouse HCC cell line Hep-55.1C, in combination with the ICIs that target either PD-1 or programmed death ligand 1 (PD-L1), in treating HCC [58,59]. Here, CD274 is linked to hepatocellular carcinoma.