IGFBP3 and neoplasm: The anti-tumour effects of Rec8 are caused by downregulation of cell growth-related genes (G6PD, SLC2A1, NOL3, MCM2, SNAI1, and SNAI2) and also by upregulation of both apoptosis or migration inhibitors (Gadd45G and LDHA) and tumour inhibitors (PinX1, IGFBP3, and ETS2) [121].