The BCL6 gene encodes for a TF member of the Broad-Complex, Tramtrack and Bric-a-brac/Pox virus Zinc Finger (BTB/POZ) family [9,103], which operates as a repressor and is required for germinal center (GC) B-cell development [104], while its functional deregulation (e.g., by genetic aberrations) has been linked to DLBCL [3,9]. This evidence concerns the gene BCL6 and diffuse large B-cell lymphoma.