MYCN-driving enhancers were called by comparison of H3K27ac profiles between expressing and non-expressing cells of non-MYC-amplified neuroblastoma cells lines (e.g., SKNFI, CLBGA), and the results highlighted, apart from the promoter, five cis-elements enriched for the histone activation mark in expressing cells, preserving enhancer potential (e1–e5) [123]. This evidence concerns the gene MYCN and neuroblastoma.