The TAL1 gene encodes for a basic helix-loop-helix (bHLH) TF [98,99], which is aberrantly expressed in T-ALL (>40% of all cases) [100] and its neighboring non-coding loci acquire somatic mutations necessary for the accumulation of TFBMs recognized by the MYB oncogenic TF [2,101]. The gene discussed is TAL1; the disease is acute lymphoblastic leukemia.