RNA-sequencing analysis of miR-769-3p-overexpressing OSCC cells showed that expression of the key genes related to the interleukin-2 signaling pathway, such as IL7R, IL73RA1, and ITIH4, was strongly upregulated or downregulated, with statistical significance; this finding may confer favorable clinical outcomes in patients with HNSCC. This evidence concerns the gene ITIH4 and head and neck squamous cell carcinoma.