In a study with a large number of samples (n = 236) using tissue array slides immunostained for protein gene product 9.5 (PGP9.5) to identify nerve tissue, Albo et al. [71] observed PGP9.5+ nerves in the stroma of colon adenocarcinomas in 67% of the cases, being 11% considered as having high nerve density (>20 nerves per hpf). The gene discussed is UCHL1; the disease is colon adenocarcinoma.