The immune system in its communication with the NS participates in this process and an example of this is the induction of the expression of pro-metastatic genes and genes characteristic of the M2 phenotype, such as TGFβ, in addition to the reduction in the expression of the IFN geneβ in macrophages located within the tumor microenvironment, in response to stress [9]. This evidence concerns the gene TGFB1 and neoplasm.