IRS1 and neoplasm: Briefly, reduced angiogenesis and tumor growth were induced by decreased expression of miR-126 in fibroblasts and increased miR-126 expression in endothelial cells in an miR-126-sensitive environment, which is associated with modulation of vascular endothelial growth factor (VEGF), EGF-like domain multiple 7 (EGFL7), and insulin receptor substrate 1 (IRS1) expression [156].