However, when the cells were co-exposed to LOLA, the activity of NCX was reduced in cells co-treated with ROT, whereas it was potentiated in cells co-treated with 6-OHDA, thus suggesting a potential different effect of LOLA in the regulation of calcium homeostasis in these two experimental PD models (Figure 3G,H). The gene discussed is TLX2; the disease is Parkinson disease.