In its turn, TNF-α induces apoptosis [53], inhibiting the expression of NF-κB isoforms (e.g., c-Rel) and C-X-C chemokine receptor type 4 (CXCR4), resulting in the degeneration of nigral DAn and development of PD [54,55]. The gene discussed is NFKB1; the disease is Parkinson disease.