Of note, they showed that microglia present a genetic profile overlapping genes that are up- and downregulated in PD, once microglia can express protein deglycase (DJ-1/PARK7), PINK1, triggering receptor expressed on myeloid cells 2 (TREM2), Parkinsonism-associated deglycase 2 (PARK2), PARK7, SNCA (α-Syn), phospholipase A2 group VI (PLA2G6), ATPase cation-transporting 13A2 (ATP13A2), autophagy-related 5 (ATG5), and glucosylceramidase beta acid (GBA) [36,37]. Here, TREM2 is linked to Parkinson disease.