In most of the cells, TRP channels are expressed, and strong evidence for an essential role in airway function and associated diseases, such as CF, asthma, fibrosis and edema was demonstrated for TRPA1, TRPC6, TRPM2, TRPM5, TRPM7, TRPV2, TRPV4 and TRPV6. This evidence concerns the gene TRPM7 and cystic fibrosis.