In most of the cells, TRP channels are expressed, and strong evidence for an essential role in airway function and associated diseases, such as CF, asthma, fibrosis and edema was demonstrated for TRPA1, TRPC6, TRPM2, TRPM5, TRPM7, TRPV2, TRPV4 and TRPV6. Here, TRPM5 is linked to cystic fibrosis.