In most of the cells, TRP channels are expressed, and strong evidence for an essential role in airway function and associated diseases, such as CF, asthma, fibrosis and edema was demonstrated for TRPA1, TRPC6, TRPM2, TRPM5, TRPM7, TRPV2, TRPV4 and TRPV6. The gene discussed is TRPV4; the disease is cystic fibrosis.