TRPC6 and pulmonary arterial hypertension: While we identified no discernable differences in chronic (3 weeks) hypoxia-induced PAH (and the accompanying pulmonary vascular remodeling) in TRPC6-deficient and wild-type mice, other scientists reported that TRPC6-deficient mice exposed less PAH and pulmonary vascular remodeling after 4 weeks of hypoxia (reviewed in [164]).