Surface exposure of CRT in cancer cells responding to anthracycline mitoxantrone, a prototype ICD inducer, involves the concomitant activation of three modules: (i) an ER stress–ROS signaling mediated by the activation of the PERK-eIF2α axis; (ii) a cell death axis involving the preapoptotic cleavage of BAP31 by caspase-8 and regulated by BAX/BAK and Ca2+; and (iii) a SNARE-dependent, ER-to-Golgi anterograde secretory pathway [105]. The gene discussed is CALR; the disease is cancer.