NFKB1 and retinal degeneration: It was shown that NF-κB is activated in rd mice and light-induced retinal degeneration [147,148] Interestingly, GSK3β was shown to facilitate NF-κB transactivation by TNF-α since GSK3β deficient mouse embryonic fibroblasts exhibit defective NF-κB activation in response to TNFα [66].