The observed phenomenon of the reduction of PPARα in cirrhotic PBC livers was associated with a substantial induction of miR-155 (3.5-fold increase vs. controls, p = 0.004; Figure 2a) and miR-21 (50-fold increase vs. controls, p = 0.0001, and p = 0.01 vs. PSC; Figure 2b). This evidence concerns the gene PPARA and primary biliary cholangitis.