Exome-wide and genome-wide association studies have identified that a variant in the TM6SF2 gene (rs58542926, encoding p.Glu167Lys, E167K) is associated with reduced myocardial infarction risk and decreased plasma LDL-C levels but increased liver fat levels [7,8,9], demonstrating the paradoxical effect of TM6SF2 variant in cardiovascular and liver diseases. The gene discussed is TM6SF2; the disease is liver disorder.