In addition, we established that the cotreatment of RCE plus Oxa effectively inhibited hPD-L1 MC38 tumor growth, inducing CD8+ T cell infiltration and GrB expression in tumor tissues more than either RCE or Oxa alone, triggering an effective antitumor immune response in human PD-1/PD-L1 MC38 tumor mouse models. Here, GZMB is linked to neoplasm.