With nontoxic doses of RCE or Oxa in co-culture systems, we discovered that RCE plus Oxa apparently activates hPD-1 tumor-infiltrating CD3+ T cells or tumor-infiltrating CD3+CD8+ T cells and kills hPD-L1 MC38 cells in the tumor microenvironment more than RCE or Oxa alone (Figure 1 and Figure 2). Here, CD8A is linked to neoplasm.