Based on the extreme correlation coefficients (Z-scores ≥ 2), 23 obstructive CAD-related genes (black: COG3, CUTC, MAML1, MORF4L1, NPTN, and VTA1; magenta: ATP6V1A, BASP1, CHMP2A, GCA, HNRNPH2, HSD17B11, NRDC, SLC16A3, TKT, and ZNF281; brown: ACSL1, AGO4, CEBPB, JPT1, RAB5IF, RNF130, and TALDO1) and 22 ACS-related genes (pink: CBX6, ERI3, FAM50A, FIBP, GNL1, HGH1, PARP6, PEX26, PHGDH, POU2F2, SNRPB, SPHK2, YIF1A, and ZNF296; darkred: ALOX5AP, APMAP, B4GALT5, CHST15, HAL, LBR, SLC22A15, and STX3) were identified. The gene discussed is RNF130; the disease is coronary artery disorder.