Previous studies demonstrated that Notch1 does not bind to the promoter of GSK3β, yet Notch2 seems bind to it [10]; these observations have shown the crosstalks between GSK3β and Notch, both GSK3β and these two Notch paralogs colocalize in the nucleus in the majority of the Notch-IC-expressing cells; however, the interaction of Notch3 and GSK3β in EMT, a potential key step in breast cancer metastasis that contributes to breast cancer-related deaths, remains unclear. The gene discussed is NOTCH2; the disease is breast cancer.