In addition, cancer cells highjack immune checkpoints to induce cytotoxic LT anergy: for example, the expression of Programmed Death-Ligand 1 (PD-L1) by cancer cells inhibits TLs’ cytotoxic activity upon binding with the Programmed Death-1 (PD-1) receptor and allow immune evasion [17]. The gene discussed is CD274; the disease is cancer.