In conclusion, and consistently with what was shown by Pozzi and collaborators in colon cancer cells [30], we found that cetuximab, alone or with cisplatin, can trigger the emission of several DAMPs (including CRT, HMGB1, and type I IFN response) in HNSCC cell lines, according to different patterns and/or intensity. This evidence concerns the gene HMGB1 and head and neck squamous cell carcinoma.