GPT and hepatocellular carcinoma: Furthermore, higher blood levels of transaminase enzymes (both AST and ALT), which are usually not associated with HCC development, were observed with miR-22 deficiency in obese mice and the long-term effects of DEN exposure (Figure 3B), reflecting hereby important hepatic stress/injury through mechanisms potentially distinct from cell death [45,46,47,48,49,50,51].