THBS1 and liver cancer: Among all non-metabolic potential miR-22 targets uncovered by our proteomic analysis, we showed that thrombospondin 1 (TSP1) is a direct target of miR-22 in hepatic cells and that this factor is consistently upregulated in miR-22-deficient hepatic tissues and downregulated in miR-22-overexpressing hepatic cancer cells.