Further supporting a tumor-suppressor role for miR-22, oncogenes such as galectin-1 (LGALS1) [31], ezrin (EZR) [32], histone deacetylase 4 (HDAC4) [33] tyrosine 3-monooxygenase/tryptophan 5-monooxygenase (YWHAZ) [28], specificity protein 1 (SP1) [34], and basigin (CD147) [27] were reported to be hepatic targets of miR-22. The gene discussed is SP1; the disease is neoplasm.