Other studies have shown a direct relationship between c-Myc and GLS expression—Gao and colleagues reported that c-Myc transcriptionally represses miR-23a and miR-23b, leading to the higher expression of GLS, which upregulates the glutamine catabolism in human P-493B lymphoma cells and PC3 prostate cancer cells [173]. The gene discussed is GLS; the disease is prostate cancer.