Genetic manipulations in several melanoma cell lines by either the knockdown of endogenously mutated GRM3 or the introduction of lentiviruses with identified mutations of GRM3 into melanoma cells with wild type endogenous GRM3 led to decreased or increased cell proliferation and migration respectively, suggesting the mutated GRM3 to be a driver in melanoma pathogenesis [125]. The gene discussed is GRM3; the disease is melanoma.