AKT1 and neoplasm: The mGluR1-mediated upregulation of the PI3K/AKT/mTOR/HIF-1α pathway promotes increased expression of angiogenic factors, such as vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8)—molecules shown to be responsible for the vasculature expansion required for tumor growth and metastasis to distal sites [57].