Zhang et al. [59] reported that Myc induces histone deacetylation and histone trimethylation to inhibit miR-29 expression in B-cell lymphoma (BCL), as evidenced by Myc can recruit histone deacetylase 3 (HDAC3) and zeste homologue 2 (EZH2) to the miR-29 promoter to form C-Myc/HDAC3/EZH2 co-repressor complex, which leads to miR-29 transcriptional silencing [59]. This evidence concerns the gene EZH2 and B-cell non-Hodgkin lymphoma.