Although at first sight it seems paradoxical that KO mice develop a higher level of lung fibrosis, while this zinc finger protein is upregulated in IPF, there are many examples of antifibrotic molecules overexpressed in IPF lung tissues that, when downregulated in experimental models, provoke an increased fibrotic response [21,22,23]. This evidence concerns the gene ZNF146 and idiopathic pulmonary fibrosis.