Consistently, decreased OPA1 (Figure 2C,E) and MFN2 expression (Figure 2H,K) and increased DRP1 (Figure 2M,O) and FIS1 levels (Figure 2Q,S) were observed in the cortices of 2×Tg-AD animals than the Ctr ones. The gene discussed is MFN2; the disease is Alzheimer disease.