To extend the present study findings, we investigated neuronal morphology using Nissl staining technology and found that irregular morphologies with loss of Nissl substance were exhibited in the neurons from the cortex of the APP/PS1 brain; however, by infusing AAV-Pgc-1alpha, an obvious inhibition in neuronal apoptosis was displayed in the cytoplasm of AD cortices. Here, PPARGC1A is linked to Alzheimer disease.