Thus, this study can be divided into two parts as follows: (1) to investigate the association of Pgc-1alpha gene variants with AD-relevant neuronal apoptosis and the protein expression involved in mitochondrial fusion and fission, as well as mitochondrial distribution, morphology and membrane potential (MMP); and (2) to explore the intervention effects of PGC-1a on AD pathology and AD-like neurobehavioral abnormalities and its potential mechanism with a particular focus on mitochondrial dynamic. Here, PPARGC1A is linked to Alzheimer disease.