To confirm the notion that apoptosis contributes to AD pathology [18], using N2A cell line, we compared the expression of B cell lymphoma/leukemia-2 (Bcl-2) and Bcl-2 associated X protein (BAX), two parameters that are associated with cell apoptosis between pCDNA- and APPswe-transfected cells. This evidence concerns the gene BCL2 and Alzheimer disease.