To gain more insight into the role of PGC-1α in mitochondrial dynamics and neurobehavioral abnormalities in AD, the Vgc of pAAV-MCS-Ppargc1α-m-FLAG-HA (AAV-Pgc-1alpha) was microinjected into LPtA cortices of APP/PS1 brains to force PGC-1α overexpression (Figure 6A). This evidence concerns the gene PPARGC1A and Alzheimer disease.