Based on study findings that PGC-1a inhibits Rotenone-induced dopaminergic neurotoxicity involved in the regulation of both fusion and fission proteins, thus determining mitochondrial network structure [11], and that PGC-1a stimulates the activity of the MFN2 promoter [12], which mediated mitochondrial transport and the expression of motor protein in human spinal motor neurons [13], we contend that PGC-1a potentially plays an important role in regulating mitochondrial dynamics and function in neurons in AD. Here, MFN2 is linked to Alzheimer disease.