PPARGC1A and Alzheimer disease: Using Aβ and PGC-1a antibodies, we found that increased aggregation in Aβ plaques (Figure 1B,C,G) was accompanied by reduced expression in PGC-1a levels (Figure 1A,F) in the cortex of AD patients than the control ones, suggesting the relevance of PGC-1a varies with AD pathology.