HPSE and breast cancer: In agreement with the in vivo findings (Figure 5), in vitro Mφ derived from heparanase-null mice (KO-Mφ), differently from Mφ derived from wt mice (wt-Mφ), failed to upregulate ERα in murine (E0771, Figure 6A) and human (T47D, Figure 6B) BC cell lines following SFA stimulation.