KMT2A and acute myeloid leukemia: Figure 1 shows that most of the H3K79me2 presented as a narrow peak at the 5′ end of the gene and a lesser number of H3K79me2 peaks were quite broad, up to 471,096 bp long. The gene with the broadest H3K79me2 domain was JMJD1C (chr10:63,163,632-63,634,728) (Figure S1), a known target of the KMT2A-AF9 fusion protein and an oncogene essential to the self-renewal of AML cells [26].