Genes with the broad H3K79me2 domain and listed as present in the top 5% of an AML cell line include CUB And Sushi Multiple Domains 3 (CSMD3, MV4-11), Twist Family BHLH Transcription Factor 1 (TWIST1, THP-1), and Ephrin A5 (EFNA5, MOLM-13). This evidence concerns the gene EFNA5 and acute myeloid leukemia.