Its anti-PAH action was also connected with reduction in HIF-1ɑ and HIF-2ɑ protein levels and their downstream targets PDK1 (pyruvate dehydrogenase kinase 1), RhoA (Ras homolog gene family, member A), ROCK1 and ROCK2 (rho-associated coiled-coil containing protein kinases 1 and 2), and their downstream CyPA (cyclophilin A) and Bsg (basigin) [79]. This evidence concerns the gene ROCK1 and pulmonary arterial hypertension.