INS and metabolic dysfunction-associated steatotic liver disease: For instance, a double blind, randomized, controlled proof-of-principle study reported that allogenic donor FMT in individuals with hepatic steatosis produced beneficial changes in hepatic gene expression and in metabolites involved in inflammation and lipid metabolism [221]; in addition, another randomized, controlled trial shows that allogenic FMT in patients with NAFLD can reduce small intestinal permeability, but do not improve insulin resistance nor reduce hepatic fat fraction [222].