Activation of small GTPase RhoA, and Rho-Associated Coiled-coil Kinase (ROCK) in brain ECs via stroke promotes the association between endothelial NO Synthase (eNOS) and cav-1 [134], leading to eNOS inhibition following its translocation to the caveolae compartments [153,154,155]. The gene discussed is CAV1; the disease is stroke disorder.