As Sam68 has been related to both leptin and insulin-dependent PI3K and MAPK pathway activation in different cellular systems and there is not much information related to the expression of Sam68 in insulin signaling in GCs from healthy and PCOS women, we aim to investigate the role of this protein in the signal transduction pathways that are activated by insulin in the GCs from healthy donors. The gene discussed is LEP; the disease is polycystic ovary syndrome.