KCNB1 and Alzheimer disease: First, Western blotting analyses on the hippocampal lysates from 3-month-old Tg2576 mice revealed a significant increase in the KV2.1 protein levels in comparison with the WT hippocampal lysates, hence providing the first evidence, to our knowledge, that the KV2.1 protein expression is modulated in a transgenic in vivo model of AD.