In concordance with what we found regarding the MAM’s considerable association with the inflammatory response in diabetes, there were a significant number of interactions between altered MAM proteins in the diabetic condition and inflammatory mediators such as interleukin-1β (IL-1β), NF-kappa-B inhibitor alpha (NFκBIA), and Forkhead box protein O1 (FOXO1), which is known to regulate the response to oxidative stress [44] (Figure 6). This evidence concerns the gene FOXO1 and diabetes mellitus.