When studying the effect of topoisomerase I inhibitor topotecan (TPT) on VEGF induced by hypoxia in human neuroblastoma cells, it was found that TPT, a camptothecin analogue, can inhibit the synthesis and transactivation of HIF-1α protein, and thereby inhibits the expression of HIF-1α target gene VEGF, shows certain anti-angiogenic activity, and inhibits the angiogenesis and growth of neuroblastoma [119]. Here, HIF1A is linked to neuroblastoma.