In addition, another team has demonstrated that N-butyryl-5-methoxytryptamine (NB-5-MT), a derivative of melatonin, can reduce the expression of HIF-1α protein and the transcription of HIF-1α target genes, and has a high strong anti-angiogenesis effect in tumors, which can be used as a potential new anti-tumor drug [106]. The gene discussed is HIF1A; the disease is neoplasm.