The expression of the P2X7 receptor can be induced by elevated HIF-1α under hypoxia, and then P2X7 can phosphorylate ERK and AKT signaling pathways and increase the accumulation of NF-κB, which promotes tumor cell EMT by regulating the expression of MMP2 and MMP9 [51,52]. Here, NFKB1 is linked to neoplasm.