HIF1A and neoplasm: Under hypoxic conditions, HIF-1 is involved in the transcriptional regulation of glycolytic genes such as glucose transporter proteins and glycolytic enzymes; HIF-1 also maintains the redox dynamic balance in tumor cells under hypoxic conditions by inhibiting fatty acid oxidation; in addition, HIF-1 can affect mitochondrial metabolism by regulating the production of reactive oxygen species and signal production in mitochondria [14].