Glyceollins, plant antitoxins isolated from soybean, were found to reduce HIF-1α levels in a variety of tumor cell lines by inhibiting the PI3K/AKT/mTOR pathway to block HIF-1α translation and by inhibiting the binding of HIF-1α to Hsp90 to promote HIF-1α degradation, thereby reducing the stability of HIF-1α [131]. This evidence concerns the gene AKT1 and neoplasm.