BACE1 and hepatocellular carcinoma: Additionally, BACE1-AS is up-regulated in the hepatocellular carcinoma cell line (HCC), and increased BACE1-AS can regulate the expression of the gene CELF1 by down-regulating the level of miR-377-3p, resulting in the activation of the EMT pathway and increased tumor invasion and metastasis (Table A1) [83].