LDHA and colonic neoplasm: Experiments demonstrated that these ETP members inhibited the formation of the HIF-1α/p300 complex in prostate cancer cell lines and colon cancer cell lines and attenuated HIF-1α transcription of the downstream target genes VEGF, lactate dehydrogenase A (LDHA), and enolase-1 (ENO1), thereby effectively inhibiting tumor angiogenesis and growth [141].