APOE and atherosclerosis: Treg plasticity in atherosclerosis has been reported in aortas of a Western diet (WD)-fed apolipoprotein E (ApoE)−/− mice [21,22] and prolonged exposure to inflammatory cytokines such as interferon-γ (IFNγ), IL 12, and IL-27 via direct activation of the phosphoinositide 3-kinases (PI3K)-protein kinase B (AKT) and Forkhead box protein O1 (Foxo1)/3 pathway [23].