Although our panel is still largely relevant, reflecting the more common causes of HSP (SPAST, ATL1, REEP1, CYP7B1, SPG7, and SPG11), it lacks genes like KIF1A (SPG30), which is currently known to cause 10–15% of all autosomal dominant HSP cases [40]. The gene discussed is SPG11; the disease is hereditary spastic paraplegia.