By performing survival analysis based on gene pair mutation, we observed that the mutation of nine gene pairs, such as “SERPINB3|RELN”, “KAT6B|RELN”, and “SERPINB3|PEG3”, were significantly correlated with patient survival in all four independent melanoma datasets (Figure 3A, log-rank test p-value < 0.05). The gene discussed is RELN; the disease is melanoma.