Finally, a total of 12 pathways including 4 PPs (Neutrophil extracellular trap formation, MAPK signaling pathway, Base excision repair, and Mismatch repair) and 8 NPs (Chemokine Receptors, Autoimmune thyroid disease, Regulation of autophagy, Citrate cycle (TCA cycle), DNA checkpoints, TGF-b Family Members Receptors) were observed to have significantly higher NES in responders or non-responders in more than three datasets (Figure 4A,B). The gene discussed is TGFB1; the disease is autoimmune thyroid disease.