Univariate logistic regression showed that irisin < 10.4 ng/mL (OR = 1.52; p = 0.001), LV hypertrophy (OR = 1.12; p = 0.044), BMI > 34 kg/m2 (OR = 1.07; p = 0.046), NT-proBNP > 750 pmol/mL (OR = 1.54; p = 0.001), age (OR = 1.03; p = 0.048), LAVI > 34 mL/m2 (OR = 1.20; p = 0.001) and E/e’ > 11 (OR = 1.12; p = 0.001) were independent predictors for HFpEF in T2DM patients (Table 2). Here, FNDC5 is linked to type 2 diabetes mellitus.